PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

The WD40-repeat protein DDB2 is essential for efficient recognition and subsequent removal of ultraviolet (UV)-induced DNA lesions by nucleotide excision repair (NER). However, how DDB2 promotes NER in chromatin is poorly understood. Here, we identify poly(ADP-ribose) polymerase 1 (PARP1) as a novel...

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Detalles Bibliográficos
Autores principales: Pines, Alex, Vrouwe, Mischa G., Marteijn, Jurgen A., Typas, Dimitris, Luijsterburg, Martijn S., Cansoy, Medine, Hensbergen, Paul, Deelder, André, de Groot, Anton, Matsumoto, Syota, Sugasawa, Kaoru, Thoma, Nicolas, Vermeulen, Wim, Vrieling, Harry, Mullenders, Leon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471223/
https://www.ncbi.nlm.nih.gov/pubmed/23045548
http://dx.doi.org/10.1083/jcb.201112132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471223/
https://www.ncbi.nlm.nih.gov/pubmed/23045548
http://dx.doi.org/10.1083/jcb.201112132

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