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PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1
The WD40-repeat protein DDB2 is essential for efficient recognition and subsequent removal of ultraviolet (UV)-induced DNA lesions by nucleotide excision repair (NER). However, how DDB2 promotes NER in chromatin is poorly understood. Here, we identify poly(ADP-ribose) polymerase 1 (PARP1) as a novel...
Autores principales: | Pines, Alex, Vrouwe, Mischa G., Marteijn, Jurgen A., Typas, Dimitris, Luijsterburg, Martijn S., Cansoy, Medine, Hensbergen, Paul, Deelder, André, de Groot, Anton, Matsumoto, Syota, Sugasawa, Kaoru, Thoma, Nicolas, Vermeulen, Wim, Vrieling, Harry, Mullenders, Leon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471223/ https://www.ncbi.nlm.nih.gov/pubmed/23045548 http://dx.doi.org/10.1083/jcb.201112132 |
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