Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition

This study was set to investigate antiproliferative potential of dentatin (a natural coumarin isolated from Clausena excavata Burm. F) against prostate cancer and to delineate the underlying mechanism of action. Treatment with dentatin dose-dependently inhibited cell growth of PC-3 and LNCaP prostat...

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Detalles Bibliográficos
Autores principales: Arbab, Ismail Adam, Looi, Chung Yeng, Abdul, Ahmad Bustamam, Cheah, Foo Kit, Wong, Won Fen, Sukari, Mohd Aspollah, Abdullah, Rasedee, Mohan, Syam, Syam, Suvitha, Arya, Aditya, Mohamed Elhassan Taha, Manal, Muharram, Bushra, Rais Mustafa, Mohd, Ibrahim Abdelwahab, Siddig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471446/
https://www.ncbi.nlm.nih.gov/pubmed/23091559
http://dx.doi.org/10.1155/2012/856029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471446/
https://www.ncbi.nlm.nih.gov/pubmed/23091559
http://dx.doi.org/10.1155/2012/856029

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