Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding

Alcoholism is frequently co-morbid with posttraumatic stress disorder (PTSD) but it is unclear how alcohol impacts neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical...

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Detalles Bibliográficos
Autores principales: Holmes, Andrew, Fitzgerald, Paul J., MacPherson, Kathryn P., DeBrouse, Lauren, Colacicco, Giovanni, Flynn, Shaun M., Masneuf, Sophie, Pleil, Kristen E., Li, Chia, Marcinkiewcz, Catherine A., Kash, Thomas L., Gunduz-Cinar, Ozge, Camp, Marguerite
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471649/
https://www.ncbi.nlm.nih.gov/pubmed/22941108
http://dx.doi.org/10.1038/nn.3204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471649/
https://www.ncbi.nlm.nih.gov/pubmed/22941108
http://dx.doi.org/10.1038/nn.3204

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