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Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding
Alcoholism is frequently co-morbid with posttraumatic stress disorder (PTSD) but it is unclear how alcohol impacts neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471649/ https://www.ncbi.nlm.nih.gov/pubmed/22941108 http://dx.doi.org/10.1038/nn.3204 |
| _version_ | 1782246460686860288 |
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| author | Holmes, Andrew Fitzgerald, Paul J. MacPherson, Kathryn P. DeBrouse, Lauren Colacicco, Giovanni Flynn, Shaun M. Masneuf, Sophie Pleil, Kristen E. Li, Chia Marcinkiewcz, Catherine A. Kash, Thomas L. Gunduz-Cinar, Ozge Camp, Marguerite |
| author_facet | Holmes, Andrew Fitzgerald, Paul J. MacPherson, Kathryn P. DeBrouse, Lauren Colacicco, Giovanni Flynn, Shaun M. Masneuf, Sophie Pleil, Kristen E. Li, Chia Marcinkiewcz, Catherine A. Kash, Thomas L. Gunduz-Cinar, Ozge Camp, Marguerite |
| author_sort | Holmes, Andrew |
| collection | PubMed |
| description | Alcoholism is frequently co-morbid with posttraumatic stress disorder (PTSD) but it is unclear how alcohol impacts neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic (IL) mPFC neurons in vivo, and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear. |
| format | Online Article Text |
| id | pubmed-3471649 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34716492013-04-01 Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding Holmes, Andrew Fitzgerald, Paul J. MacPherson, Kathryn P. DeBrouse, Lauren Colacicco, Giovanni Flynn, Shaun M. Masneuf, Sophie Pleil, Kristen E. Li, Chia Marcinkiewcz, Catherine A. Kash, Thomas L. Gunduz-Cinar, Ozge Camp, Marguerite Nat Neurosci Article Alcoholism is frequently co-morbid with posttraumatic stress disorder (PTSD) but it is unclear how alcohol impacts neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic (IL) mPFC neurons in vivo, and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear. 2012-09-02 2012-10 /pmc/articles/PMC3471649/ /pubmed/22941108 http://dx.doi.org/10.1038/nn.3204 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Holmes, Andrew Fitzgerald, Paul J. MacPherson, Kathryn P. DeBrouse, Lauren Colacicco, Giovanni Flynn, Shaun M. Masneuf, Sophie Pleil, Kristen E. Li, Chia Marcinkiewcz, Catherine A. Kash, Thomas L. Gunduz-Cinar, Ozge Camp, Marguerite Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding |
| title | Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding |
| title_full | Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding |
| title_fullStr | Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding |
| title_full_unstemmed | Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding |
| title_short | Chronic alcohol remodels prefrontal neurons and disrupts NMDA receptor-mediated fear extinction encoding |
| title_sort | chronic alcohol remodels prefrontal neurons and disrupts nmda receptor-mediated fear extinction encoding |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471649/ https://www.ncbi.nlm.nih.gov/pubmed/22941108 http://dx.doi.org/10.1038/nn.3204 |
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