A Screen for Selective Killing of Cells with Chromosomal Instability Induced by a Spindle Checkpoint Defect

BACKGROUND: The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome number. Defects in the checkpoint lead to Chromosomal INstability (CIN), which is linked to the progression of tumors with poor clinical outcomes such as drug resistance and metastasis. As CIN is not fo...

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Detalles Bibliográficos
Autores principales: Shaukat, Zeeshan, Wong, Heidi W. S., Nicolson, Shannon, Saint, Robert B., Gregory, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471812/
https://www.ncbi.nlm.nih.gov/pubmed/23077619
http://dx.doi.org/10.1371/journal.pone.0047447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471812/
https://www.ncbi.nlm.nih.gov/pubmed/23077619
http://dx.doi.org/10.1371/journal.pone.0047447

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