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DCM-Related Tropomyosin Mutants E40K/E54K Over-Inhibit the Actomyosin Interaction and Lead to a Decrease in the Number of Cycling Cross-Bridges
Two DCM mutants (E40K and E54K) of tropomyosin (Tm) were examined using the thin-filament extraction/reconstitution technique. The effects of the Ca(2+), ATP, phosphate (Pi), and ADP concentrations on isometric tension and its transients were studied at 25°C, and the results were compared to thos...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471818/ https://www.ncbi.nlm.nih.gov/pubmed/23077624 http://dx.doi.org/10.1371/journal.pone.0047471 |