Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic β-Cells

In glucose-induced insulin secretion from pancreatic β-cells, a population of insulin granules fuses with the plasma membrane without the typical docking process (newcomer granule fusions), however, its mechanism is unclear. In this study, we investigated the PI3K signaling pathways involved in the...

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Detalles Bibliográficos
Autores principales: Aoyagi, Kyota, Ohara-Imaizumi, Mica, Nishiwaki, Chiyono, Nakamichi, Yoko, Ueki, Kohjiro, Kadowaki, Takashi, Nagamatsu, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471824/
https://www.ncbi.nlm.nih.gov/pubmed/23077605
http://dx.doi.org/10.1371/journal.pone.0047381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471824/
https://www.ncbi.nlm.nih.gov/pubmed/23077605
http://dx.doi.org/10.1371/journal.pone.0047381

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