Phosphorylation of C3a Receptor at Multiple Sites Mediates Desensitization, β-Arrestin-2 Recruitment and Inhibition of NF-κB Activity in Mast Cells

BACKGROUND: Phosphorylation of G protein coupled receptors (GPCRs) by G protein coupled receptor kinases (GRKs) and the subsequent recruitment of β-arrestins are important for their desensitization. Using shRNA-mediated gene silencing strategy, we have recently shown that GRK2, GRK3 and β-arrestin-2...

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Detalles Bibliográficos
Autores principales: Gupta, Kshitij, Subramanian, Hariharan, Klos, Andreas, Ali, Hydar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471852/
https://www.ncbi.nlm.nih.gov/pubmed/23077507
http://dx.doi.org/10.1371/journal.pone.0046369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471852/
https://www.ncbi.nlm.nih.gov/pubmed/23077507
http://dx.doi.org/10.1371/journal.pone.0046369

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