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Soluble IL-2Rα (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice
A strong association exists between mutations at the IL2 receptor alpha chain (CD25) gene locus and susceptibility to a number of T cell driven autoimmune diseases. Interestingly, the presence of certain CD25 susceptibility alleles has been correlated with significantly increased levels of the solub...
Autores principales: | Russell, Shane E., Moore, Anne C., Fallon, Padraic G., Walsh, Patrick T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471880/ https://www.ncbi.nlm.nih.gov/pubmed/23077668 http://dx.doi.org/10.1371/journal.pone.0047748 |
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