Lipophilic Prodrugs of FR900098 Are Antimicrobial against Francisella novicida In Vivo and In Vitro and Show GlpT Independent Efficacy

Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells. The first committed step of the MEP pathway is catalyz...

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Detalles Bibliográficos
Autores principales: McKenney, Elizabeth S., Sargent, Michelle, Khan, Hameed, Uh, Eugene, Jackson, Emily R., Jose, Géraldine San, Couch, Robin D., Dowd, Cynthia S., van Hoek, Monique L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471904/
https://www.ncbi.nlm.nih.gov/pubmed/23077474
http://dx.doi.org/10.1371/journal.pone.0038167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471904/
https://www.ncbi.nlm.nih.gov/pubmed/23077474
http://dx.doi.org/10.1371/journal.pone.0038167

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