Thermal Unfolding Pathway of PHD2 Catalytic Domain in Three Different PHD2 Species: Computational Approaches

Prolyl hydroxylase domain 2 containing protein (PHD2) is a key protein in regulation of angiogenesis and metastasis. In normoxic condition, PHD2 triggers the degradation of hypoxia-inducible factor 1 (HIF-1α) that induces the expression of hypoxia response genes. Therefore the correct function of PH...

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Detalles Bibliográficos
Autores principales: Hadi-Alijanvand, Hamid, Proctor, Elizabeth A., Goliaei, Bahram, Dokholyan, Nikolay V., Moosavi-Movahedi, Ali A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471951/
https://www.ncbi.nlm.nih.gov/pubmed/23077544
http://dx.doi.org/10.1371/journal.pone.0047061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471951/
https://www.ncbi.nlm.nih.gov/pubmed/23077544
http://dx.doi.org/10.1371/journal.pone.0047061

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