Exploring PHD Fingers and H3K4me0 Interactions with Molecular Dynamics Simulations and Binding Free Energy Calculations: AIRE-PHD1, a Comparative Study

PHD fingers represent one of the largest families of epigenetic readers capable of decoding post-translationally modified or unmodified histone H3 tails. Because of their direct involvement in human pathologies they are increasingly considered as a potential therapeutic target. Several PHD/histone-p...

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Detalles Bibliográficos
Autores principales: Spiliotopoulos, Dimitrios, Spitaleri, Andrea, Musco, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471955/
https://www.ncbi.nlm.nih.gov/pubmed/23077531
http://dx.doi.org/10.1371/journal.pone.0046902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471955/
https://www.ncbi.nlm.nih.gov/pubmed/23077531
http://dx.doi.org/10.1371/journal.pone.0046902

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