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Glucose Decouples Intracellular Ca(2+) Activity from Glucagon Secretion in Mouse Pancreatic Islet Alpha-Cells

The mechanisms of glucagon secretion and its suppression by glucose are presently unknown. This study investigates the relationship between intracellular calcium levels ([Ca(2+)](i)) and hormone secretion under low and high glucose conditions. We examined the effects of modulating ion channel activi...

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Detalles Bibliográficos
Autores principales: Le Marchand, Sylvain J., Piston, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471958/
https://www.ncbi.nlm.nih.gov/pubmed/23077547
http://dx.doi.org/10.1371/journal.pone.0047084