Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

BACKGROUND: Fibrillar amyloid-like deposits and co-deposits of tau and α-synuclein are found in several common neurodegenerative diseases. Recent evidence indicates that small oligomers are the most relevant toxic aggregate species. While tau fibril formation is well-characterized, factors influenci...

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Detalles Bibliográficos
Autores principales: Nübling, Georg, Bader, Benedikt, Levin, Johannes, Hildebrandt, Jenna, Kretzschmar, Hans, Giese, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472288/
https://www.ncbi.nlm.nih.gov/pubmed/22824345
http://dx.doi.org/10.1186/1750-1326-7-35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472288/
https://www.ncbi.nlm.nih.gov/pubmed/22824345
http://dx.doi.org/10.1186/1750-1326-7-35

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