Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

BACKROUND: Aspartyl aminopeptidase (DNPEP), with specificity towards an acidic amino acid at the N-terminus, is the only mammalian member among the poorly understood M18 peptidases. DNPEP has implicated roles in protein and peptide metabolism, as well as the renin-angiotensin system in blood pressur...

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Detalles Bibliográficos
Autores principales: Chaikuad, Apirat, Pilka, Ewa S, De Riso, Antonio, von Delft, Frank, Kavanagh, Kathryn L, Vénien-Bryan, Catherine, Oppermann, Udo, Yue, Wyatt W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472314/
https://www.ncbi.nlm.nih.gov/pubmed/22720794
http://dx.doi.org/10.1186/1472-6807-12-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472314/
https://www.ncbi.nlm.nih.gov/pubmed/22720794
http://dx.doi.org/10.1186/1472-6807-12-14

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