Cargando…

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

BACKROUND: Aspartyl aminopeptidase (DNPEP), with specificity towards an acidic amino acid at the N-terminus, is the only mammalian member among the poorly understood M18 peptidases. DNPEP has implicated roles in protein and peptide metabolism, as well as the renin-angiotensin system in blood pressur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chaikuad, Apirat, Pilka, Ewa S, De Riso, Antonio, von Delft, Frank, Kavanagh, Kathryn L, Vénien-Bryan, Catherine, Oppermann, Udo, Yue, Wyatt W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472314/ https://www.ncbi.nlm.nih.gov/pubmed/22720794 http://dx.doi.org/10.1186/1472-6807-12-14

Ejemplares similares

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates
por: Egger, Sigrid, et al.
Publicado: (2012)

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase
por: Egger, Sigrid, et al.
Publicado: (2011)

Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits
por: Shafqat, Naeem, et al.
Publicado: (2013)

Characterization of aspartyl aminopeptidase from Toxoplasma gondii
por: Zheng, Jun, et al.
Publicado: (2016)

High resolution structure of an M23 peptidase with a substrate analogue
por: Grabowska, Maja, et al.
Publicado: (2015)

The role of Aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy
por: Gontijo, Fabiano de Assis, et al.
Publicado: (2017)

Mechanism and Substrate Recognition of Human Holo ACP Synthase
por: Bunkoczi, Gabor, et al.
Publicado: (2007)

Docking simulation between HIV peptidase inhibitors and Trypanosoma cruzi aspartyl peptidase
por: Castilho, Vanessa V. S., et al.
Publicado: (2018)

Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases
por: Pilka, Ewa S., et al.
Publicado: (2009)

Therapeutic and biotechnological applications of substrate specific microbial aminopeptidases
por: Nandan, Arya, et al.
Publicado: (2020)

The M18 aspartyl aminopeptidase of Plasmodium falciparum binds to human erythrocyte spectrin in vitro
por: Lauterbach, Sonja B, et al.
Publicado: (2008)

Chlorophyte aspartyl aminopeptidases: Ancient origins, expanded families, new locations, and secondary functions
por: Park, Sang-Youl, et al.
Publicado: (2017)

Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity
por: Jones, Stephen K., et al.
Publicado: (2015)

The Structure of Phosphorylase Kinase Holoenzyme at 9.9 Å Resolution and Location of the Catalytic Subunit and the Substrate Glycogen Phosphorylase
por: Vénien-Bryan, Catherine, et al.
Publicado: (2009)

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens
por: Chaikuad, Apirat, et al.
Publicado: (2015)

A Novel Glutamyl (Aspartyl)-Specific Aminopeptidase A from Lactobacillus delbrueckii with Promising Properties for Application
por: Stressler, Timo, et al.
Publicado: (2016)

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases
por: Malcolm, Tess R., et al.
Publicado: (2021)

Peptidase Substrates via Global Peptide Profiling
por: Tagore, Debarati M., et al.
Publicado: (2008)

Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds
por: Wanat, Weronika, et al.
Publicado: (2019)

The Predatory Bacterium Bdellovibrio bacteriovorus Aspartyl-tRNA Synthetase Recognizes tRNA(Asn) as a Substrate
por: Alperstein, Ariel, et al.
Publicado: (2014)

Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension
por: Chaikuad, Apirat, et al.
Publicado: (2019)

Molecular characterization of a novel aspartyl aminopeptidase that contributes to the increase in glutamic acid content in chicken meat during cooking
por: Yuhara, Hitomi, et al.
Publicado: (2021)

HIV Aspartyl Peptidase Inhibitors Interfere with Cellular Proliferation, Ultrastructure and Macrophage Infection of Leishmania amazonensis
por: Santos, Lívia O., et al.
Publicado: (2009)

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence
por: Clarke, Starlynn C., et al.
Publicado: (2016)

The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach
por: Joshi, Shilvi, et al.
Publicado: (2017)

Development of a fluorogenic small substrate for dipeptidyl peptidase-4
por: Ogawa, Futa, et al.
Publicado: (2017)

The Bacteroidetes Q-Rule: Pyroglutamate in Signal Peptidase I Substrates
por: Bochtler, Matthias, et al.
Publicado: (2018)

The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates
por: Zheng, Jiahuan, et al.
Publicado: (2023)

Repositioning drug strategy against Trypanosoma cruzi: lessons learned from HIV aspartyl peptidase inhibitors
por: Sangenito, Leandro Stefano, et al.
Publicado: (2022)

Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
por: Sokołowska, Iwona, et al.
Publicado: (2015)

Fingerprinting the Substrate Specificity of M1 and M17 Aminopeptidases of Human Malaria, Plasmodium falciparum
por: Poreba, Marcin, et al.
Publicado: (2012)

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties
por: Hutchinson, Jonathan P., et al.
Publicado: (2021)

Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of aspartyl aminopeptidase from the apeB gene of Pseudomonas aeruginosa. Retraction
por: Natarajan, Sampath, et al.
Publicado: (2012)

Aminopeptidase A and dipeptidyl peptidase 4: a pathogenic duo in Alzheimer’s disease?
por: Checler, Frédéric, et al.
Publicado: (2022)

Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO
por: Ortega, Manuel A., et al.
Publicado: (2014)

3D QSAR, pharmacophore and molecular docking studies of known inhibitors and designing of novel inhibitors for M18 aspartyl aminopeptidase of Plasmodium falciparum
por: Kumari, Madhulata, et al.
Publicado: (2016)

Peptidases in human bronchoalveolar lining fluid, macrophages, and epithelial cells: Dipeptidyl (amino)peptidase IV, aminopeptidase N, and dipeptidyl (carboxy)peptidase (angiotensin-converting enzyme)()
por: Juillerat-Jeanneret, Lucienne, et al.
Publicado: (1997)

Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia
por: Röhnert, Peter, et al.
Publicado: (2012)

ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG : I. EFFECT OF PEPTIDASE SUBSTRATES AND INHIBITORS
por: Austen, K. F., et al.
Publicado: (1961)

Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition
por: Kumar, Prashant, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_omfeqbjpbda7jat7l5su7lohk0