Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA

Biosynthesis of coenzyme A (CoA) requires a five-step process using pantothenate and cysteine in the fission yeast Schizosaccharomyces pombe. CoA contains a thiol (SH) group, which reacts with carboxylic acid to form thioesters, giving rise to acyl-activated CoAs such as acetyl-CoA. Acetyl-CoA is es...

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Detalles Bibliográficos
Autores principales: Nakamura, Takahiro, Pluskal, Tomáš, Nakaseko, Yukinobu, Yanagida, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472395/
https://www.ncbi.nlm.nih.gov/pubmed/23091701
http://dx.doi.org/10.1098/rsob.120117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472395/
https://www.ncbi.nlm.nih.gov/pubmed/23091701
http://dx.doi.org/10.1098/rsob.120117

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