Activated Mutant NRas(Q61K) Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism

Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation. NRas signals downstream of the major melanocyte tyrosine kinase receptor c-kit and activated NRas results in increased signaling via the...

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Detalles Bibliográficos
Autores principales: Li, Ang, Ma, Yafeng, Jin, Meng, Mason, Susan, Mort, Richard L, Blyth, Karen, Larue, Lionel, Sansom, Owen J, Machesky, Laura M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472562/
https://www.ncbi.nlm.nih.gov/pubmed/22718121
http://dx.doi.org/10.1038/jid.2012.186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472562/
https://www.ncbi.nlm.nih.gov/pubmed/22718121
http://dx.doi.org/10.1038/jid.2012.186

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