Dithiolethione Compounds Inhibit Akt Signaling in Human Breast and Lung Cancer Cells by Increasing PP2A Activity

The chemo-preventative effects of dithiolethione compounds are attributed to their activation of anti-oxidant response elements (ARE) by reacting with the Nrf2/Keap1 protein complex. In this study, we demonstrate anti-proliferative effects of the dithiolethione compound ACS-1 in human cancer cell li...

Descripción completa

Detalles Bibliográficos
Autores principales: Switzer, Christopher H., Ridnour, Lisa A., Cheng, Robert Y.S., Sparatore, Anna, Soldato, Piero Del, Moody, Terry W., Vitek, Michael P., Roberts, David D., Wink, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472634/
https://www.ncbi.nlm.nih.gov/pubmed/19701246
http://dx.doi.org/10.1038/onc.2009.244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472634/
https://www.ncbi.nlm.nih.gov/pubmed/19701246
http://dx.doi.org/10.1038/onc.2009.244

Ejemplares similares