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Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
Extra chromosome copies markedly alter the physiology of eukaryotic cells, but the underlying reasons are not well understood. We created human trisomic and tetrasomic cell lines and determined the quantitative changes in their transcriptome and proteome in comparison with their diploid counterparts...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Molecular Biology Organization
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472693/ https://www.ncbi.nlm.nih.gov/pubmed/22968442 http://dx.doi.org/10.1038/msb.2012.40 |