A Combination of 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation Studies of Benzimidazole-Quinolinone Derivatives as iNOS Inhibitors

Inducible Nitric Oxide Synthase (iNOS) has been involved in a variety of diseases, and thus it is interesting to discover and optimize new iNOS inhibitors. In previous studies, a series of benzimidazole-quinolinone derivatives with high inhibitory activity against human iNOS were discovered. In this...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hao, Zan, Jinhang, Yu, Guangyun, Jiang, Ming, Liu, Peixun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472740/
https://www.ncbi.nlm.nih.gov/pubmed/23109848
http://dx.doi.org/10.3390/ijms130911210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472740/
https://www.ncbi.nlm.nih.gov/pubmed/23109848
http://dx.doi.org/10.3390/ijms130911210

Ejemplares similares