Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis

Genomic instability, a hallmark of cancer, occurs preferentially at specific genomic regions known as common fragile sites (CFSs). CFSs are evolutionarily conserved and late replicating regions with AT-rich sequences, and CFS instability is correlated with cancer. In the last decade, much progress h...

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Detalles Bibliográficos
Autores principales: Ma, Ke, Qiu, Li, Mrasek, Kristin, Zhang, Jun, Liehr, Thomas, Quintana, Luciana Gonçalves, Li, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472787/
https://www.ncbi.nlm.nih.gov/pubmed/23109895
http://dx.doi.org/10.3390/ijms130911974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472787/
https://www.ncbi.nlm.nih.gov/pubmed/23109895
http://dx.doi.org/10.3390/ijms130911974

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