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Integrating Chemical Footprinting Data into RNA Secondary Structure Prediction
Chemical and enzymatic footprinting experiments, such as shape (selective 2′-hydroxyl acylation analyzed by primer extension), yield important information about RNA secondary structure. Indeed, since the [Image: see text]-hydroxyl is reactive at flexible (loop) regions, but unreactive at base-paired...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473038/ https://www.ncbi.nlm.nih.gov/pubmed/23091593 http://dx.doi.org/10.1371/journal.pone.0045160 |