The Ionic and Hydrophobic Interactions Are Required for the Auto Activation of Cysteine Proteases of Plasmodium falciparum

The Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3 are major hemoglobinases and potential antimalarial drug targets. Our previous studies demonstrated that these enzymes are equipped with specific domains for specific functions. Structural and functional analysis of falcipains...

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Detalles Bibliográficos
Autores principales: Sundararaj, Srinivasan, Singh, Deepak, Saxena, Ajay K., Vashisht, Kapil, Sijwali, Puran S., Dixit, Rajnikant, Pandey, Kailash C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473063/
https://www.ncbi.nlm.nih.gov/pubmed/23077573
http://dx.doi.org/10.1371/journal.pone.0047227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473063/
https://www.ncbi.nlm.nih.gov/pubmed/23077573
http://dx.doi.org/10.1371/journal.pone.0047227

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