Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue

Antibodies against adeno-associated viral (AAV) vectors are highly prevalent in humans. Both preclinical and clinical studies showed that antibodies against AAV block transduction even at low titers, particularly when the vector is introduced into the bloodstream. Here we measured the neutralizing a...

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Detalles Bibliográficos
Autores principales: Mingozzi, F, Chen, Y, Edmonson, S C, Zhou, S, Thurlings, R M, Tak, P P, High, K A, Vervoordeldonk, M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473155/
https://www.ncbi.nlm.nih.gov/pubmed/22786533
http://dx.doi.org/10.1038/gt.2012.55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473155/
https://www.ncbi.nlm.nih.gov/pubmed/22786533
http://dx.doi.org/10.1038/gt.2012.55

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