HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

BACKGROUND: Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, thereby compromising p53 activity. Therefore, lymphoma is a suitable model for studying the therapeutic value of disrupting the HDM2-p53 interaction by small-molecule inhibitors (SMIs). HDM2 have been developed...

Descripción completa

Detalles Bibliográficos
Autores principales: Sosin, Angela M, Burger, Angelika M, Siddiqi, Aisha, Abrams, Judith, Mohammad, Ramzi M, Al-Katib, Ayad M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473265/
https://www.ncbi.nlm.nih.gov/pubmed/22989009
http://dx.doi.org/10.1186/1756-8722-5-57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473265/
https://www.ncbi.nlm.nih.gov/pubmed/22989009
http://dx.doi.org/10.1186/1756-8722-5-57

Ejemplares similares