Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice

Endoplasmic reticulum (ER) thiol oxidases initiate a disulfide relay to oxidatively fold secreted proteins. We found that combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1α, ERO1β, and PRDX4 compromised the extracellular matrix in mice and interfered with the intracell...

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Detalles Bibliográficos
Autores principales: Zito, Ester, Hansen, Henning Gram, Yeo, Giles S.H., Fujii, Junichi, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473360/
https://www.ncbi.nlm.nih.gov/pubmed/22981861
http://dx.doi.org/10.1016/j.molcel.2012.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473360/
https://www.ncbi.nlm.nih.gov/pubmed/22981861
http://dx.doi.org/10.1016/j.molcel.2012.08.010

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