Efficient Detection, Quantification and Enrichment of Subtle Allelic Alterations

Gene targeting (GT) can introduce subtle alterations into a particular locus and represents a powerful tool for genome editing. Engineered zinc finger nucleases (ZFNs) are effective for generating minor allelic alterations. Efficient detection of such minor alterations remains one of the challenges...

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Detalles Bibliográficos
Autores principales: Chen, Jianbin, Zhang, Xi, Wang, Tiansu, Li, Zhendong, Guan, Guijun, Hong, Yunhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473374/
https://www.ncbi.nlm.nih.gov/pubmed/23075543
http://dx.doi.org/10.1093/dnares/dss023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473374/
https://www.ncbi.nlm.nih.gov/pubmed/23075543
http://dx.doi.org/10.1093/dnares/dss023

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