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Rereplication in emi1-Deficient Zebrafish Embryos Occurs through a Cdh1-Mediated Pathway
Disruption of early mitotic inhibitor 1 (Emi1) interferes with normal cell cycle progression and results in early embryonic lethality in vertebrates. During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling the accumulation of Cyclins A and B so they c...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474755/ https://www.ncbi.nlm.nih.gov/pubmed/23082190 http://dx.doi.org/10.1371/journal.pone.0047658 |