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Sphingopeptides: dihydrosphingosine‐based fusion inhibitors against wild‐type and enfuvirtide‐resistant HIV‐1

Understanding the structural organization of lipids in the cell and viral membranes is essential for elucidating mechanisms of viral fusion that lead to entry of enveloped viruses into their host cells. The HIV lipidome shows a remarkable enrichment in dihydrosphingomyelin, an unusual sphingolipid f...

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Detalles Bibliográficos
Autores principales: Ashkenazi, Avraham, Viard, Mathias, Unger, Linor, Blumenthal, Robert, Shai, Yechiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Federation of American Societies for Experimental Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475257/
https://www.ncbi.nlm.nih.gov/pubmed/22872679
http://dx.doi.org/10.1096/fj.12-215111