Probability Fluxes and Transition Paths in a Markovian Model Describing Complex Subunit Cooperativity in HCN2 Channels

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are voltage-gated tetrameric cation channels that generate electrical rhythmicity in neurons and cardiomyocytes. Activation can be enhanced by the binding of adenosine-3′,5′-cyclic monophosphate (cAMP) to an intracellular cyclic...

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Detalles Bibliográficos
Autores principales: Benndorf, Klaus, Kusch, Jana, Schulz, Eckhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475657/
https://www.ncbi.nlm.nih.gov/pubmed/23093920
http://dx.doi.org/10.1371/journal.pcbi.1002721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475657/
https://www.ncbi.nlm.nih.gov/pubmed/23093920
http://dx.doi.org/10.1371/journal.pcbi.1002721

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