Cargando…

Leishmania donovani Argininosuccinate Synthase Is an Active Enzyme Associated with Parasite Pathogenesis

BACKGROUND: Gene expression analysis in Leishmania donovani (Ld) identified an orthologue of the urea cycle enzyme, argininosuccinate synthase (LdASS), that was more abundantly expressed in amastigotes than in promastigotes. In order to characterize in detail this newly identified protein in Leishma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lakhal-Naouar, Ines, Jardim, Armando, Strasser, Rona, Luo, Shen, Kozakai, Yukiko, Nakhasi, Hira L., Duncan, Robert C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475689/ https://www.ncbi.nlm.nih.gov/pubmed/23094117 http://dx.doi.org/10.1371/journal.pntd.0001849

Ejemplares similares

Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management
por: Sardar, Abul Hasan, et al.
Publicado: (2016)

Deletion of Ubiquitin Fold Modifier Protein Ufm1 Processing Peptidase Ufsp in L. donovani Abolishes Ufm1 Processing and Alters Pathogenesis
por: Gannavaram, Sreenivas, et al.
Publicado: (2014)

Identification and Characterization of Genes Involved in Leishmania Pathogenesis: The Potential for Drug Target Selection
por: Duncan, Robert, et al.
Publicado: (2011)

Retraction: Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management
Publicado: (2023)

Immunization with Live Attenuated Leishmania donovani Centrin(−/−) Parasites Is Efficacious in Asymptomatic Infection
por: Ismail, Nevien, et al.
Publicado: (2017)

Immunity to Visceral Leishmaniasis Using Genetically Defined Live-Attenuated Parasites
por: Selvapandiyan, Angamuthu, et al.
Publicado: (2012)

Mitochondrial Associated Ubiquitin Fold Modifier-1 Mediated Protein Conjugation in Leishmania donovani
por: Gannavaram, Sreenivas, et al.
Publicado: (2011)

Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization
por: Gannavaram, Sreenivas, et al.
Publicado: (2017)

Ly6C(hi) inflammatory monocytes promote susceptibility to Leishmania donovani infection
por: Terrazas, Cesar, et al.
Publicado: (2017)

Fitness of Leishmania donovani Parasites Resistant to Drug Combinations
por: García-Hernández, Raquel, et al.
Publicado: (2015)

Candidates for Balancing Selection in Leishmania donovani Complex Parasites
por: Grace, Cooper Alastair, et al.
Publicado: (2021)

Centrin-Deleted Leishmania donovani Parasites Help CD4(+) T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200–CD200R Immune Inhibitory Axis
por: Singh, Rakesh K., et al.
Publicado: (2018)

Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis
por: Bhattacharya, Parna, et al.
Publicado: (2016)

Mapping the Antigenicity of the Parasites in Leishmania donovani Infection by Proteome Serology
por: Forgber, Michael, et al.
Publicado: (2006)

Production of leishmanin skin test antigen from Leishmania donovani for future reintroduction in the field
por: Dey, Ranadhir, et al.
Publicado: (2023)

Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable Protective Immune Response in Hamsters
por: Fiuza, Jacqueline Araújo, et al.
Publicado: (2016)

Antimonial Resistance in Leishmania donovani Is Associated with Increased In Vivo Parasite Burden
por: Vanaerschot, Manu, et al.
Publicado: (2011)

Argininosuccinate synthase 1, arginine deprivation therapy and cancer management
por: Sun, Naihui, et al.
Publicado: (2022)

Application of rapid in vitro co-culture system of macrophages and T-cell subsets to assess the immunogenicity of dogs vaccinated with live attenuated Leishmania donovani centrin deleted parasites (LdCen(−/−))
por: Viana, Kelvinson Fernandes, et al.
Publicado: (2016)

LEISHMANIA DONOVANI IN THE PERIPHERAL BLOOD
por: Young, Charles W., et al.
Publicado: (1923)

Role of cAMP Signaling in the Survival and Infectivity of the Protozoan Parasite, Leishmania donovani
por: Biswas, Arunima, et al.
Publicado: (2011)

Leishmania donovani-Induced Increase in Macrophage Bcl-2 Favors Parasite Survival
por: Pandey, Rajeev Kumar, et al.
Publicado: (2016)

Unveiling Cerebral Leishmaniasis: parasites and brain inflammation in Leishmania donovani infected mice
por: Melo, Guilherme D., et al.
Publicado: (2017)

Hemophagocytosis induced by Leishmania donovani infection is beneficial to parasite survival within macrophages
por: Morimoto, Ayako, et al.
Publicado: (2019)

Dermotropic Leishmania donovani in Sri Lanka: visceralizing potential in clinical and preclinical studies
por: KARIYAWASAM, K. K. G. D. U. L., et al.
Publicado: (2018)

Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53
por: Miyamoto, Takafumi, et al.
Publicado: (2017)

Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner
por: Musa, Md. Abu, et al.
Publicado: (2019)

Genetic diversity of Leishmania donovani that causes cutaneous leishmaniasis in Sri Lanka: a cross sectional study with regional comparisons
por: Kariyawasam, Udeshika Lakmini, et al.
Publicado: (2017)

Leishmania donovani parasite requires Atg8 protein for infectivity and survival under stress
por: Giri, Sagnik, et al.
Publicado: (2019)

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1
por: Locke, Matthew, et al.
Publicado: (2016)

A pan-cancer analysis of the role of argininosuccinate synthase 1 in human tumors
por: Ding, Qiang, et al.
Publicado: (2023)

Proteomic analysis of the secretome of Leishmania donovani
por: Silverman, J Maxwell, et al.
Publicado: (2008)

Surface antigens of Leishmania donovani promastigotes
Publicado: (1983)

Vaccine Development Against Leishmania donovani
por: Das, Amrita, et al.
Publicado: (2012)

Leishmania donovani bodies in bone marrow
por: Ali, Natasha, et al.
Publicado: (2014)

Synthesis and in vitro Screening of 29, 30-Dibromo-28-oxoallobetulin against Parasitic Protozoans, Leishmania donovani and Leishmania Major
por: Ghosh, P., et al.
Publicado: (2015)

Non-Vesicular Lipid Transport Machinery in Leishmania donovani: Functional Implications in Host-Parasite Interaction
por: Das, Koushik, et al.
Publicado: (2023)

Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency
por: Herrera Sanchez, Maria Beatriz, et al.
Publicado: (2017)

The identification of kala-azar and the discovery of Leishmania donovani.
por: Gibson, M E
Publicado: (1983)

Leishmania donovani and Cutaneous Leishmaniasis, Sri Lanka
por: Siriwardana, H. V. Yamuna D., et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_c5mrckjb6e1bqtss72un6nkb8i