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Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans

Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is expressed in all diabetes-relevant tissues and mediates cytokine-induced insulin resistance. We investigated whether common single nucleotide polymorphisms (SNPs) in the MAP4K4 locus associate with glucose intolerance, insulin resis...

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Detalles Bibliográficos
Autores principales: Sartorius, Tina, Staiger, Harald, Ketterer, Caroline, Heni, Martin, Machicao, Fausto, Guilherme, Adilson, Grallert, Harald, Schulze, Matthias B., Boeing, Heiner, Stefan, Norbert, Fritsche, Andreas, Czech, Michael P., Häring, Hans-Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475716/
https://www.ncbi.nlm.nih.gov/pubmed/23094072
http://dx.doi.org/10.1371/journal.pone.0047647