A Spiroligomer α-Helix Mimic That Binds HDM2, Penetrates Human Cells and Stabilizes HDM2 in Cell Culture

We demonstrate functionalized spiroligomers that mimic the HDM2-bound conformation of the p53 activation domain. Spiroligomers are stereochemically defined, functionalized, spirocyclic monomers coupled through pairs of amide bonds to create spiro-ladder oligomers [1]. Two series of spiroligomers wer...

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Detalles Bibliográficos
Autores principales: Brown, Zachary Z., Akula, Kavitha, Arzumanyan, Alla, Alleva, Jennifer, Jackson, Marcus, Bichenkov, Eugeney, Sheffield, Joel B., Feitelson, Mark A., Schafmeister, Christian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475717/
https://www.ncbi.nlm.nih.gov/pubmed/23094022
http://dx.doi.org/10.1371/journal.pone.0045948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475717/
https://www.ncbi.nlm.nih.gov/pubmed/23094022
http://dx.doi.org/10.1371/journal.pone.0045948

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