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Large intestine-targeted nanoparticle-releasing oral vaccine to control genitorectal viral infection

Both rectal and vaginal mucosal surfaces serve as transmission routes for pathogenic microorganisms. Vaccination through large intestinal mucosa, previously proven protective for both mucosal sites in animal studies, can be achieved successfully by direct intra-colorectal (i.c.r.) administration, wh...

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Detalles Bibliográficos
Autores principales: Zhu, Qing, Talton, James, Zhang, Guofeng, Cunningham, Tshaka, Wang, Zijian, Waters, Robert C., Kirk, James, Eppler, Bärbel, Dennis M, Klinman, Sui, Yongjun, Gagnon, Susan, Belyakov, Igor M., Mumper, Russell J., Berzofsky, Jay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475749/
https://www.ncbi.nlm.nih.gov/pubmed/22797811
http://dx.doi.org/10.1038/nm.2866