C. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context

Vertebrate Tob/BTG proteins inhibit cell proliferation when overexpressed in tissue culture cells, and they can function as tumor suppressors in mice. The single Caenorhabditis elegans Tob/BTG ortholog, FOG-3, by contrast, was identified from its loss-of-function phenotype as a regulator of sperm fa...

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Detalles Bibliográficos
Autores principales: Snow, Joshua J., Lee, Myon-Hee, Verheyden, Jamie, Kroll-Conner, Peggy L., Kimble, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475796/
https://www.ncbi.nlm.nih.gov/pubmed/22797076
http://dx.doi.org/10.1038/onc.2012.291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475796/
https://www.ncbi.nlm.nih.gov/pubmed/22797076
http://dx.doi.org/10.1038/onc.2012.291

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