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C. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context
Vertebrate Tob/BTG proteins inhibit cell proliferation when overexpressed in tissue culture cells, and they can function as tumor suppressors in mice. The single Caenorhabditis elegans Tob/BTG ortholog, FOG-3, by contrast, was identified from its loss-of-function phenotype as a regulator of sperm fa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475796/ https://www.ncbi.nlm.nih.gov/pubmed/22797076 http://dx.doi.org/10.1038/onc.2012.291 |