Fragment screening of cyclin G-associated kinase by weak affinity chromatography

Fragment-based drug discovery (FBDD) has become a new strategy for drug discovery where lead compounds are evolved from small molecules. These fragments form low affinity interactions (dissociation constant (K(D)) = mM − μM) with protein targets, which require fragment screening methods of sufficien...

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Detalles Bibliográficos
Autores principales: Meiby, Elinor, Knapp, Stefan, Elkins, Jonathan M., Ohlson, Sten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475971/
https://www.ncbi.nlm.nih.gov/pubmed/22918538
http://dx.doi.org/10.1007/s00216-012-6335-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475971/
https://www.ncbi.nlm.nih.gov/pubmed/22918538
http://dx.doi.org/10.1007/s00216-012-6335-6

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