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Fragment screening of cyclin G-associated kinase by weak affinity chromatography
Fragment-based drug discovery (FBDD) has become a new strategy for drug discovery where lead compounds are evolved from small molecules. These fragments form low affinity interactions (dissociation constant (K(D)) = mM − μM) with protein targets, which require fragment screening methods of sufficien...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475971/ https://www.ncbi.nlm.nih.gov/pubmed/22918538 http://dx.doi.org/10.1007/s00216-012-6335-6 |