Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells

BACKGROUND: Since cholangiocarcinoma has a poor prognosis, several epidermal growth factor receptor (EGFR)-targeted therapies with antibody or small molecule inhibitor treatment have been proposed. However, their effect remains limited. The present study sought to understand the molecular genetic ch...

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Detalles Bibliográficos
Autores principales: Gui, Anping, Kobayashi, Akira, Motoyama, Hiroaki, Kitazawa, Masato, Takeoka, Michiko, Miyagawa, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476963/
https://www.ncbi.nlm.nih.gov/pubmed/22591401
http://dx.doi.org/10.1186/1471-2407-12-179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476963/
https://www.ncbi.nlm.nih.gov/pubmed/22591401
http://dx.doi.org/10.1186/1471-2407-12-179

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