Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

BACKGROUND: The pore-forming protein perforin is central to the granule-exocytosis pathway used by cytotoxic lymphocytes to kill abnormal cells. Although this mechanism of killing is conserved in bony vertebrates, cytotoxic cells are present in other chordates and invertebrates, and their cytotoxic...

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Detalles Bibliográficos
Autores principales: D’Angelo, Michael E, Dunstone, Michelle A, Whisstock, James C, Trapani, Joseph A, Bird, Phillip I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477005/
https://www.ncbi.nlm.nih.gov/pubmed/22551122
http://dx.doi.org/10.1186/1471-2148-12-59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477005/
https://www.ncbi.nlm.nih.gov/pubmed/22551122
http://dx.doi.org/10.1186/1471-2148-12-59

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