Rationalization of paclitaxel insensitivity of yeast β-tubulin and human βIII-tubulin isotype using principal component analysis

BACKGROUND: The chemotherapeutic agent paclitaxel arrests cell division by binding to the hetero-dimeric protein tubulin. Subtle differences in tubulin sequences, across eukaryotes and among β-tubulin isotypes, can have profound impact on paclitaxel-tubulin binding. To capture the experimentally obs...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Lalita, Bhattacharya, Bhabatarak, Basu, Gautam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477043/
https://www.ncbi.nlm.nih.gov/pubmed/22849332
http://dx.doi.org/10.1186/1756-0500-5-395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477043/
https://www.ncbi.nlm.nih.gov/pubmed/22849332
http://dx.doi.org/10.1186/1756-0500-5-395

Ejemplares similares