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Rationalization of paclitaxel insensitivity of yeast β-tubulin and human βIII-tubulin isotype using principal component analysis

BACKGROUND: The chemotherapeutic agent paclitaxel arrests cell division by binding to the hetero-dimeric protein tubulin. Subtle differences in tubulin sequences, across eukaryotes and among β-tubulin isotypes, can have profound impact on paclitaxel-tubulin binding. To capture the experimentally obs...

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Detalles Bibliográficos
Autores principales:	Das, Lalita, Bhattacharya, Bhabatarak, Basu, Gautam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477043/ https://www.ncbi.nlm.nih.gov/pubmed/22849332 http://dx.doi.org/10.1186/1756-0500-5-395

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