Repositioning Antimicrobial Agent Pentamidine as a Disruptor of the Lateral Interactions of Transmembrane Domain 5 of EBV Latent Membrane Protein 1

The lateral transmembrane protein-protein interactions (PPI) have been regarded as “undruggable” despite their importance in many essential biological processes. The homo-trimerization of transmembrane domain 5 (TMD-5) of latent membrane protein 1 (LMP-1) is critical for the constitutive oncogenic a...

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Detalles Bibliográficos
Autores principales: Wang, Xiaohui, Fiorini, Zeno, Smith, Christina, Zhang, Yingning, Li, Jing, Watkins, Linda R., Yin, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477141/
https://www.ncbi.nlm.nih.gov/pubmed/23094078
http://dx.doi.org/10.1371/journal.pone.0047703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477141/
https://www.ncbi.nlm.nih.gov/pubmed/23094078
http://dx.doi.org/10.1371/journal.pone.0047703

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