Cargando…

Humanized Mouse Model of Skin Inflammation Is Characterized by Disturbed Keratinocyte Differentiation and Influx of IL-17A Producing T Cells

Humanized mouse models offer a challenging possibility to study human cell function in vivo. In the huPBL-SCID-huSkin allograft model human skin is transplanted onto immunodeficient mice and allowed to heal. Thereafter allogeneic human peripheral blood mononuclear cells are infused intra peritoneall...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Oliveira, Vivian L., Keijsers, Romy R. M. C., van de Kerkhof, Peter C. M., Seyger, Marieke M. B., Fasse, Esther, Svensson, Lars, Latta, Markus, Norsgaard, Hanne, Labuda, Tord, Hupkens, Pieter, van Erp, Piet E. J., Joosten, Irma, Koenen, Hans J. P. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477148/ https://www.ncbi.nlm.nih.gov/pubmed/23094018 http://dx.doi.org/10.1371/journal.pone.0045509

Ejemplares similares

Intradermal injection of low dose human regulatory T cells inhibits skin inflammation in a humanized mouse model
por: Landman, Sija, et al.
Publicado: (2018)

Successful Regulatory T Cell-Based Therapy Relies on Inhibition of T Cell Effector Function and Enrichment of FOXP3+ Cells in a Humanized Mouse Model of Skin Inflammation
por: Landman, S., et al.
Publicado: (2020)

Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review
por: Landman, Sija, et al.
Publicado: (2021)

Increased dermal expression of chromatin-associated protein HMGB1 and concomitant T-cell expression of the DNA RAGE in patients with psoriasis vulgaris
por: Strohbuecker, Lisa, et al.
Publicado: (2019)

Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles
por: Mulder, Patrick P. G., et al.
Publicado: (2021)

DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4(+)CD25(high) FOXP3(+) Regulatory T Cells but Does Not Affect Their Suppressive Capacity
por: Landman, Sija, et al.
Publicado: (2018)

Perfusion measured by laser speckle contrast imaging as a predictor for expansion of psoriasis lesions
por: Schaap, Mirjam J., et al.
Publicado: (2021)

Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro-inflammatory cytokines
por: Mulder, Patrick P.G., et al.
Publicado: (2022)

Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis
por: Niehues, Hanna, et al.
Publicado: (2021)

Psoriasis in Children and Adolescents: Diagnosis, Management and Comorbidities
por: Bronckers, I. M. G. J., et al.
Publicado: (2015)

Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis
por: de Groot, Martijn J, et al.
Publicado: (2013)

Understanding the Acute Skin Injury Mechanism Caused by Player-Surface Contact During Soccer: A Survey and Systematic Review
por: van den Eijnde, Wilbert A.J., et al.
Publicado: (2014)

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
por: Li, Hui, et al.
Publicado: (2018)

Immunological Monitoring of Renal Transplant Recipients to Predict Acute Allograft Rejection Following the Discontinuation of Tacrolimus
por: Kreijveld, Ellen, et al.
Publicado: (2008)

An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro
por: Urbano, Paulo C. M., et al.
Publicado: (2018)

Metabolic Pathways Involved in Regulatory T Cell Functionality
por: Kempkes, Rosalie W. M., et al.
Publicado: (2019)

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4(pos)CD25(high) T Cells for Immunotherapy
por: Peters, Jorieke H., et al.
Publicado: (2008)

Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells
por: He, Xuehui, et al.
Publicado: (2017)

The Effect of Lifestyle Changes on Disease Severity and Quality of Life in Patients with Plaque Psoriasis: A Narrative Review
por: van Acht, Maartje R, et al.
Publicado: (2022)

The number of CCR5 expressing CD4+ T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study
por: Meijerink, Hinta, et al.
Publicado: (2014)

Lymphocyte subsets in peripheral blood of patients with moderate-to-severe versus mild plaque psoriasis
por: Langewouters, A. M. G., et al.
Publicado: (2007)

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells
por: He, Xuehui, et al.
Publicado: (2016)

Presumptive brain influx of large neutral amino acids and the effect of phenylalanine supplementation in patients with Tyrosinemia type 1
por: van Ginkel, Willem G., et al.
Publicado: (2017)

Contribution of transient and sustained calcium influx, and sensitization to depolarization-induced contractions of the intact mouse aorta
por: Fransen, Paul, et al.
Publicado: (2012)

Inhibiting the Ca(2+) Influx Induced by Human CSF
por: Drews, Anna, et al.
Publicado: (2017)

Altered Calcium Influx Pathways in Cancer-Associated Fibroblasts
por: Sadras, Francisco, et al.
Publicado: (2021)

Kinetics of gene expression and bone remodelling in the clinical phase of collagen-induced arthritis
por: Denninger, Katja CM, et al.
Publicado: (2015)

STIMulating Ca(2+) influx
por: LeBrasseur, Nicole
Publicado: (2006)

Efflux and Influx of Erythrocyte Water
por: Olmstead, Edwin G.
Publicado: (1960)

N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx
por: Veldman, R J, et al.
Publicado: (2004)

Calcipotriol/Betamethasone Dipropionate Foam Inhibits Th17 Cytokine Secretion and Improves Epidermal Barrier Markers in a Human Th17 Skin Inflammation Model
por: Lovato, Paola, et al.
Publicado: (2021)

Delineating Zinc Influx Mechanisms during Platelet Activation
por: Kuravi, Sahithi J., et al.
Publicado: (2023)

Public health measures during the COVID-19 pandemic through the lens of community organisations and networks in the Netherlands (2020–2021): five lessons for pandemic decision-making
por: Kolner, Carla, et al.
Publicado: (2022)

Multi Parameter Flow Cytometric Assessment of Regenerative Epidermis with Special Reference to the Antiproliferative Effect of Occlusion
por: van Rossum, M. M., et al.
Publicado: (1998)

Longitudinal Analysis of T and B Cell Phenotype and Function in Renal Transplant Recipients with or without Rituximab Induction Therapy
por: Kamburova, Elena G., et al.
Publicado: (2014)

Human keratinocyte sensitivity towards inflammatory cytokines varies with culture time
por: Elliott, G., et al.
Publicado: (1992)

Pulmonary granulocyte influx and impaired alveolar macrophage adenylyl cyclase responsiveness in developing respiratory distress
por: Amsterdam, J. G. C. van, et al.
Publicado: (1993)

TNFα-Signaling Modulates the Kinase Activity of Human Effector Treg and Regulates IL-17A Expression
por: Urbano, Paulo C. M., et al.
Publicado: (2020)

Redefining Strategies to Introduce Tolerance-Inducing Cellular Therapy in Human beings to Combat Autoimmunity and Transplantation Reactions
por: ten Brinke, Anja, et al.
Publicado: (2014)

Increased calcium influx in dystrophic muscle
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_otv937f1rp16cvmv3jsgkeg5ve