TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

Immunoglobulin (Ig) class switching is crucial for generating antibody diversity in humoral immunity and, if deregulated, also has severe pathological consequences. How the magnitude of Ig isotype switching is controlled is still poorly understood. Here we identify TANK-binding kinase 1 (TBK1) as a...

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Detalles Bibliográficos
Autores principales: Jin, Jin, Xiao, Yichuan, Chang, Jae-Hoon, Yu, Jiayi, Hu, Hongbo, Starr, Robyn, Brittain, George C., Chang, Mikyoung, Cheng, Xuhong, Sun, Shao-Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477307/
https://www.ncbi.nlm.nih.gov/pubmed/23023393
http://dx.doi.org/10.1038/ni.2423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477307/
https://www.ncbi.nlm.nih.gov/pubmed/23023393
http://dx.doi.org/10.1038/ni.2423

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