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Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenge

The susceptibility of the normal cellular prion protein isoform, cellular prion protein (PrP(C)), to proteolytic digestion has been well documented. In addition, a link between PrP(C) and the cytosolic protease, calpain, has been reported although the specifics of the interaction remain unclear. We...

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Detalles Bibliográficos
Autores principales: Wang, Kevin K. W., Zoltewicz, J. Susie, Chiu, Allen, Zhang, Zhiqun, Rubenstein, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477638/
https://www.ncbi.nlm.nih.gov/pubmed/23093947
http://dx.doi.org/10.3389/fneur.2012.00147