PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with (177)Lu-DOTA-bombesin analogues

BACKGROUND: Radiolabelled bombesin (BN) conjugates are promising radiotracers for imaging and therapy of breast and prostate tumours, in which BN(2)/gastrin-releasing peptide receptors are overexpressed. We describe the influence of the specific activity of a (177)Lu-DOTA-PEG(5k)-Lys-B analogue on i...

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Detalles Bibliográficos
Autores principales: Däpp, Simone, Müller, Cristina, Garayoa, Elisa García, Bläuenstein, Peter, Maes, Veronique, Brans, Luc, Tourwé, Dirk A, Schibli, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478187/
https://www.ncbi.nlm.nih.gov/pubmed/22681935
http://dx.doi.org/10.1186/2191-219X-2-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478187/
https://www.ncbi.nlm.nih.gov/pubmed/22681935
http://dx.doi.org/10.1186/2191-219X-2-24

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