Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults
BACKGROUND: We evaluated the association of regular physical exercise with the presence of non-alcoholic fatty liver disease (NAFLD) and liver enzymes in relation to obesity and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional analysis was conducted in 72,359 healthy Korean adul...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478288/ https://www.ncbi.nlm.nih.gov/pubmed/23110056 http://dx.doi.org/10.1371/journal.pone.0046819 |
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author | Bae, Ji Cheol Suh, Sunghwan Park, Se Eun Rhee, Eun Jung Park, Cheol Young Oh, Ki Won Park, Sung Woo Kim, Sun Woo Hur, Kyu Yeon Kim, Jae Hyeon Lee, Myung-Shik Lee, Moon Kyu Kim, Kwang-Won Lee, Won-Young |
author_facet | Bae, Ji Cheol Suh, Sunghwan Park, Se Eun Rhee, Eun Jung Park, Cheol Young Oh, Ki Won Park, Sung Woo Kim, Sun Woo Hur, Kyu Yeon Kim, Jae Hyeon Lee, Myung-Shik Lee, Moon Kyu Kim, Kwang-Won Lee, Won-Young |
author_sort | Bae, Ji Cheol |
collection | PubMed |
description | BACKGROUND: We evaluated the association of regular physical exercise with the presence of non-alcoholic fatty liver disease (NAFLD) and liver enzymes in relation to obesity and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional analysis was conducted in 72,359 healthy Korean adults without diabetes who participated in a comprehensive health check-up. Subjects who have been exercising regularly (more than 3 times per week, at least for 30 minutes each time and for consecutive 3 month) were categorized into exercise group. All subjects were categorized into deciles based on their body mass index (BMI) and we estimated the odds ratios (ORs) for having NAFLD according to exercise regularity in each decile. The diagnosis of NAFLD was based on ultrasonography findings. Individuals with NAFLD (n = 19,921) were analyzed separately to evaluate ORs for having elevated liver enzymes based on regularity of exercise. The risk for NAFLD was significantly reduced in exercise group with age- and sex-adjusted ORs of 0.53–0.72 for all BMI deciles except at BMI categories of <19.6 and 20.7–21.6 kg/m(2). While no difference was seen in BMI between subjects in exercise and non-exercise group across the BMI deciles, the values of body fat percentage and metabolic risk factors differed. Among NAFLD patients, subjects in exercise group had a lower risk for having elevated liver enzymes with multivariable adjusted OR of 0.85 (95% CI 0.74–0.99, for AST) and 0.74 (95% CI 0.67–0.81, for ALT) than did subjects in non-exercise group. CONCLUSIONS/SIGNIFICANCE: Regular exercise was associated with a reduced risk for having NAFLD and decreased liver enzymes in patients with NAFLD, and this relationship was also independent of obesity. |
format | Online Article Text |
id | pubmed-3478288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34782882012-10-29 Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults Bae, Ji Cheol Suh, Sunghwan Park, Se Eun Rhee, Eun Jung Park, Cheol Young Oh, Ki Won Park, Sung Woo Kim, Sun Woo Hur, Kyu Yeon Kim, Jae Hyeon Lee, Myung-Shik Lee, Moon Kyu Kim, Kwang-Won Lee, Won-Young PLoS One Research Article BACKGROUND: We evaluated the association of regular physical exercise with the presence of non-alcoholic fatty liver disease (NAFLD) and liver enzymes in relation to obesity and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional analysis was conducted in 72,359 healthy Korean adults without diabetes who participated in a comprehensive health check-up. Subjects who have been exercising regularly (more than 3 times per week, at least for 30 minutes each time and for consecutive 3 month) were categorized into exercise group. All subjects were categorized into deciles based on their body mass index (BMI) and we estimated the odds ratios (ORs) for having NAFLD according to exercise regularity in each decile. The diagnosis of NAFLD was based on ultrasonography findings. Individuals with NAFLD (n = 19,921) were analyzed separately to evaluate ORs for having elevated liver enzymes based on regularity of exercise. The risk for NAFLD was significantly reduced in exercise group with age- and sex-adjusted ORs of 0.53–0.72 for all BMI deciles except at BMI categories of <19.6 and 20.7–21.6 kg/m(2). While no difference was seen in BMI between subjects in exercise and non-exercise group across the BMI deciles, the values of body fat percentage and metabolic risk factors differed. Among NAFLD patients, subjects in exercise group had a lower risk for having elevated liver enzymes with multivariable adjusted OR of 0.85 (95% CI 0.74–0.99, for AST) and 0.74 (95% CI 0.67–0.81, for ALT) than did subjects in non-exercise group. CONCLUSIONS/SIGNIFICANCE: Regular exercise was associated with a reduced risk for having NAFLD and decreased liver enzymes in patients with NAFLD, and this relationship was also independent of obesity. Public Library of Science 2012-10-22 /pmc/articles/PMC3478288/ /pubmed/23110056 http://dx.doi.org/10.1371/journal.pone.0046819 Text en © 2012 Bae et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Bae, Ji Cheol Suh, Sunghwan Park, Se Eun Rhee, Eun Jung Park, Cheol Young Oh, Ki Won Park, Sung Woo Kim, Sun Woo Hur, Kyu Yeon Kim, Jae Hyeon Lee, Myung-Shik Lee, Moon Kyu Kim, Kwang-Won Lee, Won-Young Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults |
title | Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults |
title_full | Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults |
title_fullStr | Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults |
title_full_unstemmed | Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults |
title_short | Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults |
title_sort | regular exercise is associated with a reduction in the risk of nafld and decreased liver enzymes in individuals with nafld independent of obesity in korean adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478288/ https://www.ncbi.nlm.nih.gov/pubmed/23110056 http://dx.doi.org/10.1371/journal.pone.0046819 |
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