Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults

BACKGROUND: We evaluated the association of regular physical exercise with the presence of non-alcoholic fatty liver disease (NAFLD) and liver enzymes in relation to obesity and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional analysis was conducted in 72,359 healthy Korean adul...

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Autores principales: Bae, Ji Cheol, Suh, Sunghwan, Park, Se Eun, Rhee, Eun Jung, Park, Cheol Young, Oh, Ki Won, Park, Sung Woo, Kim, Sun Woo, Hur, Kyu Yeon, Kim, Jae Hyeon, Lee, Myung-Shik, Lee, Moon Kyu, Kim, Kwang-Won, Lee, Won-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478288/
https://www.ncbi.nlm.nih.gov/pubmed/23110056
http://dx.doi.org/10.1371/journal.pone.0046819
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author Bae, Ji Cheol
Suh, Sunghwan
Park, Se Eun
Rhee, Eun Jung
Park, Cheol Young
Oh, Ki Won
Park, Sung Woo
Kim, Sun Woo
Hur, Kyu Yeon
Kim, Jae Hyeon
Lee, Myung-Shik
Lee, Moon Kyu
Kim, Kwang-Won
Lee, Won-Young
author_facet Bae, Ji Cheol
Suh, Sunghwan
Park, Se Eun
Rhee, Eun Jung
Park, Cheol Young
Oh, Ki Won
Park, Sung Woo
Kim, Sun Woo
Hur, Kyu Yeon
Kim, Jae Hyeon
Lee, Myung-Shik
Lee, Moon Kyu
Kim, Kwang-Won
Lee, Won-Young
author_sort Bae, Ji Cheol
collection PubMed
description BACKGROUND: We evaluated the association of regular physical exercise with the presence of non-alcoholic fatty liver disease (NAFLD) and liver enzymes in relation to obesity and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional analysis was conducted in 72,359 healthy Korean adults without diabetes who participated in a comprehensive health check-up. Subjects who have been exercising regularly (more than 3 times per week, at least for 30 minutes each time and for consecutive 3 month) were categorized into exercise group. All subjects were categorized into deciles based on their body mass index (BMI) and we estimated the odds ratios (ORs) for having NAFLD according to exercise regularity in each decile. The diagnosis of NAFLD was based on ultrasonography findings. Individuals with NAFLD (n = 19,921) were analyzed separately to evaluate ORs for having elevated liver enzymes based on regularity of exercise. The risk for NAFLD was significantly reduced in exercise group with age- and sex-adjusted ORs of 0.53–0.72 for all BMI deciles except at BMI categories of <19.6 and 20.7–21.6 kg/m(2). While no difference was seen in BMI between subjects in exercise and non-exercise group across the BMI deciles, the values of body fat percentage and metabolic risk factors differed. Among NAFLD patients, subjects in exercise group had a lower risk for having elevated liver enzymes with multivariable adjusted OR of 0.85 (95% CI 0.74–0.99, for AST) and 0.74 (95% CI 0.67–0.81, for ALT) than did subjects in non-exercise group. CONCLUSIONS/SIGNIFICANCE: Regular exercise was associated with a reduced risk for having NAFLD and decreased liver enzymes in patients with NAFLD, and this relationship was also independent of obesity.
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spelling pubmed-34782882012-10-29 Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults Bae, Ji Cheol Suh, Sunghwan Park, Se Eun Rhee, Eun Jung Park, Cheol Young Oh, Ki Won Park, Sung Woo Kim, Sun Woo Hur, Kyu Yeon Kim, Jae Hyeon Lee, Myung-Shik Lee, Moon Kyu Kim, Kwang-Won Lee, Won-Young PLoS One Research Article BACKGROUND: We evaluated the association of regular physical exercise with the presence of non-alcoholic fatty liver disease (NAFLD) and liver enzymes in relation to obesity and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional analysis was conducted in 72,359 healthy Korean adults without diabetes who participated in a comprehensive health check-up. Subjects who have been exercising regularly (more than 3 times per week, at least for 30 minutes each time and for consecutive 3 month) were categorized into exercise group. All subjects were categorized into deciles based on their body mass index (BMI) and we estimated the odds ratios (ORs) for having NAFLD according to exercise regularity in each decile. The diagnosis of NAFLD was based on ultrasonography findings. Individuals with NAFLD (n = 19,921) were analyzed separately to evaluate ORs for having elevated liver enzymes based on regularity of exercise. The risk for NAFLD was significantly reduced in exercise group with age- and sex-adjusted ORs of 0.53–0.72 for all BMI deciles except at BMI categories of <19.6 and 20.7–21.6 kg/m(2). While no difference was seen in BMI between subjects in exercise and non-exercise group across the BMI deciles, the values of body fat percentage and metabolic risk factors differed. Among NAFLD patients, subjects in exercise group had a lower risk for having elevated liver enzymes with multivariable adjusted OR of 0.85 (95% CI 0.74–0.99, for AST) and 0.74 (95% CI 0.67–0.81, for ALT) than did subjects in non-exercise group. CONCLUSIONS/SIGNIFICANCE: Regular exercise was associated with a reduced risk for having NAFLD and decreased liver enzymes in patients with NAFLD, and this relationship was also independent of obesity. Public Library of Science 2012-10-22 /pmc/articles/PMC3478288/ /pubmed/23110056 http://dx.doi.org/10.1371/journal.pone.0046819 Text en © 2012 Bae et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bae, Ji Cheol
Suh, Sunghwan
Park, Se Eun
Rhee, Eun Jung
Park, Cheol Young
Oh, Ki Won
Park, Sung Woo
Kim, Sun Woo
Hur, Kyu Yeon
Kim, Jae Hyeon
Lee, Myung-Shik
Lee, Moon Kyu
Kim, Kwang-Won
Lee, Won-Young
Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults
title Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults
title_full Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults
title_fullStr Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults
title_full_unstemmed Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults
title_short Regular Exercise Is Associated with a Reduction in the Risk of NAFLD and Decreased Liver Enzymes in Individuals with NAFLD Independent of Obesity in Korean Adults
title_sort regular exercise is associated with a reduction in the risk of nafld and decreased liver enzymes in individuals with nafld independent of obesity in korean adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478288/
https://www.ncbi.nlm.nih.gov/pubmed/23110056
http://dx.doi.org/10.1371/journal.pone.0046819
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